Head-to-Head Comparison of FAPi & DOTANOC PET/CT Imaging for MTC Surveillance with Dr. Bal - Video

We are honored to have Dr. Chandresekhar Bal present "Head-to-Head Comparison of [68Ga]Ga-DOTA.SA.FAPi and [68Ga]Ga-DOTANOC Positron Emission Tomography/Computed Tomography Imaging for the Follow-Up Surveillance of Patients with Medullary Thyroid Cancer." Dr. David Pattison joins as the featured expert discussant.

0:00 Webinar

5:10 Dr. Bal presents

5:15 The Landscape of Imaging for Medullary Thyroid Carcinoma Surveillance
Dr. Bal provides an overview of medullary thyroid carcinoma (MTC), covering its embryology, epidemiology, and the need for accurate disease assessment. He discusses evolving TNM staging protocols informed by survival analyses, preoperative and postoperative imaging guidelines, and the 2015 ATA recommendations. Dr. Bal also presents 18F-DOPA PET/CT imaging for post-op recurrence evaluation in MTC as the preferred technique and discusses SSTR-targeted PET (68Ga-DOTANOC PET) for its theranostic potential.

19:15 Novel Theranostic Options on the Horizon
Dr. Bal explores the potential of fibroblast activation protein inhibitor (FAPi) PET for MTC, conducting a head-to-head comparison with DOTANOC PET/CT Imaging. He finds that FAPi PET shows better detection rates in lymph nodes, lungs, pleural thickening, and liver metastasis compared to SSTR PET. FAPi theranostics represent a promising avenue for progressive MTC, with future directions possibly favoring FAPi radioligand therapy.

40:06 Dr. Pattison presents

40:12 Molecular Imaging of MTC
Dr. Pattison provides an overview of molecular imaging of MTC, focusing on the clinical utility of PET imaging and non-FDA-approved radiotracers. Imaging options include FDG PET, 68Ga-DOTANOC/DOTATATE PET, 68Ga-CCK receptor PET, 18F-DOPA PET, MIBG SPECT, and 68Ga-FAPi PET. He highlights the superiority of 18F-DOPA for MTC diagnostic imaging and discusses the dual capacity of FAPi-PET for imaging and therapeutic delivery, noting its potential as a theranostic target in oncology.

55:05 Discussion with Q&A

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https://thancguide.org/

TIRO: Thyroid Int'l Recommendations Online
https://tiro.expert/

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